Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.
نویسندگان
چکیده
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 34 شماره
صفحات -
تاریخ انتشار 2012